Overview

This program pursues a set of overarching scientific goals: (1) to identify environmental, biological, psychosocial, epigenetic, and genetic factors that influence cancer risk, occurrence, and progression through basic, genetic and epigenetic, and epidemiologic research; (2) to clarify the impact of cancer and cancer treatment through outcomes research; (3) to develop, implement, evaluate, and disseminate educational, behavioral, and psychosocial interventions aimed at preventing cancer, improving early detection, enhancing symptom management, improving health and quality of life for cancer survivors, caregivers, and families, and advancing the science to improve palliative and end-of-life care; and (4) to advance cancer prevention, detection, and control within the broader contexts of institution and society through quality, economic, and policy studies. Program activities target five prioritized themes: disparities, tobacco cessation, obesity and nutrition, geriatric oncology, and survivorship (including symptom control and palliative care). Structurally, research within three main program sections – Epidemiology and Genetics Research, Behavioral Sciences Research, Applied Research – address these cross-cutting themes. Leading-edge research is underway in each section; examples are studies of epigenetic markers of cancer risk (Epidemiology and Genetics Research), neural correlates of nicotine addiction (Behavioral Sciences Research), and impact of Medicare policy change on access to chemotherapy (Applied Research). The program is integrally involved in forerunning national and institutional initiatives. Among these directions are: personalized medicine; patient-reported outcomes; survivorship care, including palliative and end-of-life care; increasing minority enrollment in clinical trials, incorporation of bioinformatics and complex data functions across the full research spectrum; development of quality assessment approaches; and creation of a learning healthcare environment.

High-Impact Journal Publications

Below are recent publications in high-impact journals from Cancer Center members in this program. To see journal articles for a particular member, click on the researcher's name in the Membership section.

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Lyman GH,Khorana AA. Cancer, Clots and Consensus: New Understanding of an Old Problem., . Journal of clinical oncology : official journal of the American Society of Clinical Oncology No abstract available [More ...]

Lu J,Guo H,Treekitkarnmongkol W,Li P,Zhang J,Shi B,Ling C,Zhou X,Chen T,Chiao PJ,Feng X,Seewaldt VL,Muller WJ,Sahin A,Hung MC,Yu D. 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition., , (195-207) - Cancer cell Abstract [More ...]

Khorana AA,Streiff MB,Farge D,Mandala M,Debourdeau P,Cajfinger F,Marty M,Falanga A,Lyman GH. Venous Thromboembolism Prophylaxis and Treatment in Cancer: A Consensus Statement of Major Guidelines Panels and Call to Action., . Journal of clinical oncology : official journal of the American Society of Clinical Oncology Abstract [More ...]

Weinfurt KP,Hall MA,King NM,Friedman JY,Schulman KA,Sugarman J. Disclosure of financial relationships to participants in clinical research., , (916-21) - The New England journal of medicine No abstract available [More ...]

Green RC,Roberts JS,Cupples LA,Relkin NR,Whitehouse PJ,Brown T,Eckert SL,Butson M,Sadovnick AD,Quaid KA,Chen C,Cook-Deegan R,Farrer LA. Disclosure of APOE genotype for risk of Alzheimer's disease., , (245-54) - The New England journal of medicine Abstract [More ...]

Zhou S,Degan S,Potts EN,Foster WM,Sunday ME. NPAS3 is a trachealess homolog critical for lung development and homeostasis., , (11691-6) - Proceedings of the National Academy of Sciences of the United States of America Abstract [More ...]

Cherny NI,Abernethy AP,Strasser F,Sapir R,Currow D,Zafar SY. Improving the Methodological and Ethical Validity of Best Supportive Care Studies in Oncology: Lessons From a Systematic Review., . Journal of clinical oncology : official journal of the American Society of Clinical Oncology Abstract [More ...]

Boling CL,Westman EC,Yancy WS. Comparison of weight-loss diets., , (2247; author reply 2247-8) - The New England journal of medicine No abstract available [More ...]

Muss HB,Berry DA,Cirrincione CT,Theodoulou M,Mauer AM,Kornblith AB,Partridge AH,Dressler LG,Cohen HJ,Becker HP,Kartcheske PA,Wheeler JD,Perez EA,Wolff AC,Gralow JR,Burstein HJ,Mahmood AA,Magrinat G,Parker BA,Hart RD,Grenier D,Norton L,Hudis CA,Winer EP. Adjuvant chemotherapy in older women with early-stage breast cancer., , (2055-65) - The New England journal of medicine Abstract [More ...]

Morey MC,Snyder DC,Sloane R,Cohen HJ,Peterson B,Hartman TJ,Miller P,Mitchell DC,Demark-Wahnefried W. Effects of home-based diet and exercise on functional outcomes among older, overweight long-term cancer survivors: RENEW: a randomized controlled trial., , (1883-91) - JAMA : the journal of the American Medical Association Abstract [More ...]

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Click here for these and other high-impact publications in this research program.